PRIN 2022 LS - Life Science | Università degli Studi di Messina

PNRR - Missione 4, Componente 2, Investimento 1.1

Bando Prin 2022 - Decreto Direttoriale n. 104 del 02-02-2022

L’Università di Messina ha ottenuto finanziamenti per n. 41 progetti nella seguente AREA ERC (European Research Council) LS - LIFE SCIENCE

Metabolic reprogramming and drug resistance in colon cancer: fighting the mechanisms of chemoresistance

Responsabile BERRETTA Massimiliano Giuseppe

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022HB54P9_002 - CUP: J53D23012170006

Contributo MUR: € 61.765,00 - Importo Totale: € 72.435.00

Settore ERC – LS7

Study of the Interplay among Gut Microbiota Metabolites, Vitamin D, and Sirtuins in Chronic Inflammatory Pain: New Diagnostic and Therapeutic Perspectives

Responsabile CACCAMO Daniela (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 202273HF83_001 - CUP: J53D23002990006

Contributo MUR: € 74.000,00 - Importo Totale: € 79.751,00

Settore ERC – LS2

Probing the interindividual synchronization during cooperative motor tasks at the brain, spinal, and muscular levels

Responsabile CACCIOLA Alberto (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022TSYBJH_001 - CUP: J53D23011070001

Contributo MUR: € 84.297,00 - Importo Totale: € 84.297,00

Settore ERC – LS5

Radiological, molecular and histological study of glioblastoma IDH wild-type characterized by RB1 alteration: towards the identification of a new variant potentially responsive to immunotherapy

Responsabile CAFFO Maria

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022H73242_002 - CUP: J53D23003190006

Contributo MUR: € 17.000,00 - Importo Totale: € 24.750,00

Settore ERC – LS2

Characterization of skeletal disorders linked to proteoglycan defects as a tool to get new insight on the molecular basis of glycosaminoglycan synthesis

Responsabile CAMPO Giuseppe Maurizio

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022ETJJES_003 - CUP: J53D23008980006

Contributo MUR: € 62.354,00 - Importo Totale: € 68.654,00

Settore ERC – LS1

Role of the RNA-binding Protein AUF-1 in human airway epithelium as determinant of inflammation and accelerated cell senescence in Chronic Obstructive Pulmonary Disease

Responsabile CARAMORI Gaetano

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 20223LP2X4_002 - CUP: J53D23012550006

Contributo MUR: € 64.567,00 - Importo Totale: € 98.619,00

Settore ERC – LS4

Comparative characterization of Wilms tumor in humans and pigs: in search of the optimal disease model

Responsabile CARREGA Paolo

Dipartimento PATOLOGIA UMANA DELL’ADULTO E DELLA ETA’ EVOLUTIVA G. BARRESI

Codice: 20227FX7KM_003 - CUP: J53D23001030006

Contributo MUR: € 23.068,00 - Importo Totale: € 28.182,00

Settore ERC – LS6

microRNAs regulating NLRP3 inflammasome as new prognostic markers and key regulators in oral squamous cell carcinoma

Responsabile CASILI Giovanna (Under 40)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022724RMP_002 - CUP: J53D23011930006

Contributo MUR: € 100.189,00 - Importo Totale: € 110.292,00

Settore ERC – LS7

Expression profiles of mast cells and macrophages in the tumor microenvironment of colorectal cancer: rationale to find novel biomarkers

Responsabile CERNARO Valeria (Under 40)

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022CMTZNH_002 - CUP: J53D23012700006

Contributo MUR: € 25.000,00- Importo Totale: € 52.514,00

Settore ERC – LS4

Understanding the clinical phenotypes of gestational diabetes mellitus: a multidisciplinary approach

Responsabile CORRADO Francesco

Dipartimento PATOLOGIA UMANA DELL’ADULTO E DELLA ETA’ EVOLUTIVA G. BARRESI

Codice: 2022CXMARC_002 - CUP: J53D23012710006

Contributo MUR: € 89.254,00 - Importo Totale: € 100.889,00

Settore ERC – LS4

Clinical and molecular profiles of Psychiatric endophenotypes in association with trace elements profile: a model for precision medicine (PDoRiT)

Responsabile CRISAFULLI Concetta (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022YYXKF2_001 - CUP: J53D23003310006

Contributo MUR: € 198.610,00 - Importo Totale: € 226.468,00

Settore ERC – LS2

An innovative cross-species transcriptome approach to target retinal cell dysfunction in age-related macular degeneration

Responsabile D’ANGELO Rosalia

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022PWMW5A_003 - CUP: J53D23011050006

Contributo MUR: € 35.494,00 - Importo Totale: € 59.074.00

Settore ERC – LS5

Muscle synergies and sensorimotor integration in goal directed upper limb movements

Responsabile D’AVELLA Andrea (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022YXLNR7_001 - CUP: J53D23011130006

Contributo MUR: € 106.813,00 - Importo Totale: € 145.689,00

Settore ERC – LS5

Insights into the prognostic value and immunological role of NAEs degradative enzymes in brain tumors

Responsabile ESPOSITO Emanuela (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 20223XBJYT_001 - CUP: J53D23011800006

Contributo MUR: € 145.680,00 - Importo Totale: € 168.529,00

Settore ERC – LS7

Proposal of a molecular panel on LBC-processed thyroid lesions. Evaluation of the diagnostic and prognostic role of genetic alterations including TERT promoter, BRAF (V600E) mutation and NTRK fusions analysis in thyroid malignant lesions

Responsabile FADDA Guido

Dipartimento PATOLOGIA UMANA DELL’ADULTO E DELLA ETA’ EVOLUTIVA G. BARRESI

Codice: 20229WCXST_003 - CUP: J53D23003040006

Contributo MUR: € 60.000,00 - Importo Totale: € 111.000,00

Settore ERC – LS2

From ExosoMes to mini-guts to PersonAlize THerapY in Crohn's disease - EMPATHY

Responsabile FRIES wALTER

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 202288MF8W_002 - CUP: J53D23012010006

Contributo MUR: € 74.271,00 - Importo Totale: € 106.278,00

Settore ERC – LS7

New hydrogel formulations for refractory rheumatoid arthritis

Responsabile FUSCO Roberta (PI) (Under 40)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022N2BSWP_001 - CUP: J53D23001130001

Contributo MUR: € 68.851,00 - Importo Totale: € 68.851,00

Settore ERC – LS6

Novel cardioprotective proteins and exosomes derived from fetal mesenchymal stromal cells for repairing ischemic cardiac damage and preventing heart failure

Responsabile GENOVESE Tiziana

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022RZCWWH_002 - CUP: J53D23009110001

Contributo MUR: € 97.375,00 - Importo Totale: € 97.375,00

Settore ERC – LS1

Persistence and food safety: an in-vitro study of the persister state in Listeria monocytogens strains to simulate the persistence in the food environment

Responsabile GIUFFRIDA Alessandro

Dipartimento SCIENZE VETERINARIE

Codice: 202225LHJ9_003 - CUP: J53D23006340006

Contributo MUR: € 26.103,00 - Importo Totale: € 53.299,00

Settore ERC – LS8

FORAGE-MED: Sustainable intensification of legume-based forage systems in semi-arid Mediterranean areas

Responsabile GRESTA Alessandro

Dipartimento SCIENZE VETERINARIE

Codice: 2022YELBEX_003 - CUP: J53D23010620006

Contributo MUR: € 66.046,00 - Importo Totale: € 76.673,00

Settore ERC – LS9

PHAGE-DISPLAY BASED NANOTECHNOLOGY FOR BONE TUMORS TARGETING AND TERAPHY

Responsabile CONOCI Sabrina

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022MFNTKB_002 - CUP: J53D23010230006

Contributo MUR: € 98.143,00 - Importo Totale: € 116.834,00

Settore ERC – LS9

From the mechanism of carnosine as antioxidant and anti-inflammatory agent to the design and synthesis of a novel class of bioactive compounds for treating colitis and linked -gut brain axis disorders

Responsabile IMPELLIZZERI Daniela (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022FWB4EX_001 - CUP: J53D23008990006

Contributo MUR: € 64.000,00 - Importo Totale: € 82.151,00

Settore ERC – LS1

Gravity in the brain: integration of visual and internalized gravity information for the interception of looming stimuli

Responsabile INDOVINA Iole (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022B42X54_001 - CUP: J53D23010850006

Contributo MUR: € 80.038,00 - Importo Totale: € 89.073,00

Settore ERC – LS5

Functional characterization of Kir4.1 and its involvement in age-related hearing loss

Responsabile MARINO Angela (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022YRBE8B_001 - CUP: J53D23012910006

Contributo MUR: € 80.924,00 - Importo Totale: € 96.716,00

Enforcing the THERapeutic Arsenal againsSt Emerging and Reemerging RNA Viruses

Responsabile MARINO MERLO Francesca

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022W97H54_003 - CUP: J53D23001200006

Contributo MUR: € 68.130,00 - Importo Totale: € 79.430,00

Settore ERC – LS6

Timely diagnosis of brain death, prevention of organ dysfunction and reconditioning of harvested organs. A network for clinical and translational studies to optimize organ donation and transplantation

Responsabile MAZZEO ANNA (PI)

Dipartimento PATOLOGIA UMANA DELL’ADULTO E DELLA ETA’ EVOLUTIVA G. BARRESI

Codice: 20223TWA55_001 - CUP: J53D23010740006

Contributo MUR: € 73.890,00 - Importo Totale: € 101.874,00

Settore ERC – LS5

Spinal muscular atrophy: clinical phenotypes and biomarkers at the time of the new disease modifying therapies

Responsabile: MESSINA Sonia

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022N2FHA8_002 - CUP: J53D23011030006

Contributo MUR: € 43.000,00 - Importo Totale: € 56.750,00

Settore ERC – LS5

MITOCHONDRIAL DISEASES: UNRAVELING THE CLINICAL MAZE BY OMICS AND ARTIFICIAL INTELLIGENCE

Responsabile: MUSUMECI Olimpia

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022B9WY4A_002 - CUP: J53D23010870006

Contributo MUR: € 17.717,00 - Importo Totale: € 30.578,00

Settore ERC – LS5

Extracellular vesicles from zoonotic vector-borne filarial nematodes: host-parasite interaction and clues for control strategies (NEMEXIT)

Responsabile: NAPOLI Ettore (Under 40)

Dipartimento SCIENZE VETRINARIE

Codice: 2022PX9HTE_002 - CUP: J53D23001150006

Contributo MUR: € 55.652,00 - Importo Totale: € 76.253,00

Settore ERC – LS6

Health defence by natural products as shield in highly polluted areas

Responsabile: NAVARRA Michele (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022TJ39LF_001 - CUP: J53D23012450006

Contributo MUR: € 119.900,00- Importo Totale: € 144.668,00

Settore ERC – LS7

Dissecting the mechanisms associated with cognitive deficits in Alzheimer’s disease: the Gat3 connection

Responsabile: ODDO Salvatore (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022B7AFK2_001- CUP: J53D23010860006

Contributo MUR: € 102.735,00 - Importo Totale: € 109.749,00

Settore ERC – LS5

Efficacy of a Microparticulate muco-adhesive Patch containing drug-nutraceutical Association in paTIents affected by oral mucosa alterations - Acronym : EMPATIA

Responsabile: OTERI Giacomo (PI)

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022CLLMCP_001 - CUP: J53D23008960006

Contributo MUR: € 73.300,00 - Importo Totale: € 103.805,00

Settore ERC – LS1

Deciphering the key virological determinants underlying the replicative and pathogenetic activity of Hepatitis D Virus (HDV) in treated and untreated Hepatitis B Virus and HDV coinfected patients.

Responsabile: POLLICINO Teresa (PI)

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022X2KWRK_001 - CUP: J53D23001220006

Contributo MUR: € 108.557,00 - Importo Totale: € 133.034,00

Settore ERC – LS6

On the development of neoantigen vaccine for HCC cure: from genomics of Hepatitis B Virus (HBV) integration in liver cells to immunological host response toward neoepitopes as novel immunotherapeutic approaches

Responsabile: SAITTA Carlo (Under 40)

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 20224MMB2M_002 - CUP: J53D23000990001

Contributo MUR: € 81.000,00 - Importo Totale: € 81.000,00

Settore ERC – LS6

Effect of high phosphate levels on vascular calcification and cardiovascular disease in chROnic kidney disease analyzed by transcriptome and epigenetic profiling of huMAN endoThelIal Cells (ROMANTIC)

Responsabile SANTORO Domenico

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022EFWCH8_003 - CUP: J53D23012720006

Contributo MUR: € 25.850,00- Importo Totale: € 32.850,00

Settore ERC – LS4

Circular economy: from local agri-food waste to new nutraceuticals against inflammatory bowel diseases - FENICE

Responsabile: SMERIGLIO Antonella (PI)

Dipartimento SCIENZE CHIMICHE, BIOLOGICHE, FARMACEUTICHE ED AMBIENTALI

Codice: 2022RB7938_001 - CUP: J53D23012360006

Contributo MUR: € 104.324,00 - Importo Totale: € 155.197,00

Settore ERC – LS7

Kinase inhibitors as new opportunities for therapeutic innovation in cardiometabolic diseases: from metaflammation targeting to drug repurposing

Responsabile: SQUADRITO Francesco (PI)

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 20224PR8HE_001 - CUP: J53D23011860006

Contributo MUR: € 95.800,00 - Importo Totale: € 115.800,00

Settore ERC – LS7

From muscles to brain: advanced imaging techniques to unravel motor system failure for prognosis prediction in motor neuron diseases (MNDs)

Responsabile: TOSCANO Antonio

Dipartimento MEDICINA CLINICA E SPERIMENTALE

Codice: 2022MCTA5M_002 - CUP: J53D23011010006

Contributo MUR: € 57.310,00 - Importo Totale: € 98.472,00

Settore ERC – LS5

Predictive model of osteoarthritis through the use of inertial knee brace and thermography applied to movement analysis. Get back to move!

Responsabile: TRIMARCHI Fabio

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022PZH8SX_003 - CUP: J53D23012340006

Contributo MUR: € 35.000,00 - Importo Totale: € 56.482,00

Settore ERC – LS7

FINI - Future challenges in management of recurrent/resistant Infection: development of antimicrobial Nanoparticulate systems and physical-chemical investigation of their Interactions with biofilm-associated infection

Responsabile: VENUTI Valentina (PI)

Dipartimento SCIENZE MATEMATICHE E INFORMATICHE, SCIENZE FISICHE E SCIENZE DELLA TERRA

Codice: 2022325YFW_001 - CUP: J53D23008880006

Contributo MUR: € 77.290,00 - Importo Totale: € 101.997,00

Settore ERC – LS1

Head down tilt 15° to increase collateral flow in acute ischemic stroke: a translational, multi-center, randomized, proof of concept phase 2a trial in patients treated with mechanical thrombectomy (DOWN-SUITE)

Responsabile VINCI Sergio

Dipartimento SCIENZE BIOMEDICHE, ODONTOIATRICHE E DELLE IMMAGINI MORFOLOGICHE E FUNZIONALI

Codice: 2022LNL3H3_002 - CUP: J53D23010990006

Contributo MUR: € 52.224,00 - Importo Totale: € 61.543,00

Settore ERC – LS5

PRIN 2022 LS - Life Science

PNRR - Missione 4, Componente 2, Investimento 1.1

Bando Prin 2022 - Decreto Direttoriale n. 104 del 02-02-2022

Ti interessa anche